International Society of Dermatology - Palm Coast, FL - USA

Author: Dr. Dagnachew Shibeshi
MD Dermato-Venereologist, Addis Ababa University, Faculty Medicine Department of Dermato-Venereology

ABSTRACT

Introduction
Background: Androgenic alopecia is the commonest disorder affecting both men and women. The incidence is generally greater in men than women.
Pathophysiology The genetically determined disorder is progressive resulting in gradual conversion of terminal hairs into indeterminate hairs and finally to velus hairs.
Frequency Affects 50% of men and perhaps equal number of females over the age of 40.
Mortality and morbidity
• This disorder essentially causes cosmetic problem and results in psychological problem.
Race: White women > Asian > African Americans (Africans) > Native
American.
Age: usually onset is prior to age 40 in almost all patients.
Causes AA is a genetically determined condition. Androgenic alopecia is
dominantly inherited with variable penetrance and expression. It may, however, be polygenic in penetrance.
Laboratory studies
• In case of women
- Dehydrosferone (DHEA) sulphate and testosterone
• If thyroid disorder is suspected:
- Thyrotropin level is indicated
• If telogen iffluvium is present:
- Serum iron levels
• Biopsy to identify underlying papulosguamous disorder may be indicated
Treatment
• Minoxidil
- The drug is marketed as a 2% or 5% solution with the 5% solution
being more effective
• Finasterede is given orally and used only in men
• Spironoloctone, oral contraceptives may be used in women with androgenic alopecia